Showing posts with label Liver Disease. Show all posts
Showing posts with label Liver Disease. Show all posts

Wednesday, August 11, 2010

How Can Transmission of Liver Cirrhosis

What is cirrhosis?
Cirrhosis is a scarring of the liver, resulting in fiber formation (scar) tissue associated with the destruction of the structure of normal organs. It has long been mainly the result of damage due to alcohol above, but there are many other important reasons (see below).
                                                          figure via herbalprovider
The destruction of the normal architecture and loss of liver cells, preventing normal liver. It plays an important role in digestion of food, but it also has an important role in drug metabolism and the creation of proteins, including those that help the blood to clot.

Cirrhosis is a serious disease. Only 30 percent of patients with this problem will survive five years after diagnosis and prognosis is worse when the cause is alcohol, and the patient continues to drink.

What causes the inflammation that leads to cirrhosis of the liver?
  • Excessive alcohol cirrhosis rates in the country, is directly related to the average alcohol consumption in this country. Half of all cases of cirrhosis due to alcohol abuse.
  • Chronic viral hepatitis: two major viruses of hepatitis B and C cirrhosis due to hepatitis B is common in Africa and Asia. Hepatitis C is increasingly important in Europe and the United States. Hepatitis A (infectious hepatitis) does not cause cirrhosis of the liver.
  • Primary biliary cirrhosis: is a rare disease that primarily affects women. Not because of alcohol. For some reason, the body mounts an attack on the liver in patients with primary biliary cirrhosis.
  • Hepatitis, autoimmune chronic active: another rare condition that results in immune system attacks the body and destroys liver cells.
  • Drugs and chemicals: the number of drugs and chemicals can damage the liver, but few cause cirrhosis. Some specialty drugs to monitor their effects on the liver.
  • Metabolic and inherited: they are not too many conditions that allow the accumulation of toxins in the liver. The most common is hemochromatosis, which causes excess iron deposits in the liver.

What are the symptoms of cirrhosis?
The symptoms depend on the amount of liver damage has occurred. In the initial phase can not be at all, and the symptoms can be detected in the investigation of another disease. As the disease progresses, fatigue, weakness, loss of low energy, loss of appetite, nausea, weight may develop. In the later stages of liver tries to fulfill all its functions and some or all of the following symptoms may be present.
  • Jaundice: This is a yellowing of the skin (jaundice) and eyes due to liver failure to remove a substance called bilirubin in the blood.
  • Nail changes: the shape and appearance of the nails may change. They may be more curved (clubbing) and may be white and not pink.
  • Skin changes: about a quarter of patients will be darkening of the skin.
  • Water retention: what is common to a certain stage of cirrhosis. An important function of the liver is to get rid of excess fluid by the kidneys, and when not to, fluid accumulates in the legs (edema) or abdomen (ascites).
  • Vascular disorders: the most common abnormality is marked by a spider, which is on the ground surrounded by small blood vessels. A red face is also common.
  • Bruising nosebleeds and bruising occur as a result of abnormal blood vessels and delayed clotting because the liver does not have enough clotting proteins.
  • Breast enlargement in men: the liver destroys the female sex hormone and cirrhosis of the accumulate and cause breast enlargement and shrinkage of testicles in men.
In a very advanced stage of disease, can cause serious complications. They include vomiting blood, or stomach ulcers or varicose veins entering the bottom of the gullet (esophagus). This is serious and requires hospitalization.
The liver is responsible for the disposal of toxic substances in the blood. In cirrhosis of the liver, blood, the liver can avoid these toxic substances and submit to the brain where they may lead to changes in the brain, causing confusion, drowsiness and finally coma. This is called hepatic encephalopathy. There is also a serious and require hospitalization.
Who is at risk?

  • The more a person drinks alcohol, the more likely that the development of cirrhosis. Women tend to be more sensitive than men. Therefore, it is advisable to limit alcohol consumption to 28 units per week for men and 21 units per week for women (units of alcohol a powerful liquor, beer, or half the normal size of a beer or a glass of wine).

  • Patients who have been infected with hepatitis B and hepatitis C.

  • Patients with primary biliary cirrhosis or chronic active hepatitis autoimmune disease.

  • Patients with metabolic abnormalities or hereditary.

How can I prevent cirrhosis?

  • Reduce intake of alcohol (see above).

  • Alcoholics should seek help.

  • Care must be taken to avoid the liver and if it is contained, it is important that it be treated.

  • Avoid contact with toxic chemicals in the workplace.
How is cirrhosis diagnosed?
If the clinical examination creates a suspicion of liver cirrhosis, the diagnosis can be confirmed by analysis of blood samples. While this can be confirmed by ultrasound, may be necessary to perform a liver biopsy to obtain samples of liver tissue. It can also provide information on the cause of cirrhosis.

Wrinkle
If alcohol abuse and addiction is the cause, you must stop drinking alcohol immediately. Once alcohol has damaged the liver and liver cells are exposed to even small amounts of alcohol.

With the help of friends, family and one of the organizations that specialize in helping people with alcohol problems. Your doctor will be able to help.

Activity
Try to lead an active life. This can be difficult because of fatigue and weakness, but it is worth persevering.

If your legs are swollen, it can help raise the rest.

Food
  • Avoid all alcohol.
  • Eat well-balanced diet rich in protein (only after consulting your doctor.)
  • Avoid adding salt to meals. Salt can be used in small quantities in the kitchen.
  • Subsequently, the amount of protein you eat can be reduced from time to time (based on medical opinions).
  • Vitamin and mineral supplements may be necessary.
Complications

  • Impotence in men. It is a combination of the effects of alcohol and liver cirrhosis.

  • Severe internal bleeding varices in the stomach or esophagus. This is serious and requires hospitalization.

  • Liver cancer, which occurs at a later stage in many patients with cirrhosis of the liver.

  • Blood poisoning caused by an infection, excessive fluid in the abdominal cavity (ascites).

Prospects
progressive liver damage can be stopped by removing the cause. These tips are based on alcohol. Treatment is available for a chronic infection of hepatitis B and chronic infection with hepatitis C. Excess iron can be treated by removing blood regularly. Hepatitis, autoimmune chronic active can be treated with steroids that suppress the immune system and prevent attacks liver cells.

Although the damage can be repaired, the symptoms can be relieved and controlled. If treatment begins early, the victim may be able to lead an almost normal life. If the cause is not removed, but scarring and destruction of the structure of the liver ultimately lead to liver failure and death.

How is cirrhosis treated?
In addition to removing the cause, cirrhosis of the liver can not be processed. The emphasis is on the issue and reduce the complications of the disease.

The following methods are used:
  • Diuretics (water pills) to treat fluid retention in the legs (edema) or abdomen (ascites).
  • Vitamins and mineral supplements.
  • Calorie supplements (usually sugar-based drinks) to maintain nutritional value.
  • Laxatives (usually a solution called lactulose syrup) to prevent constipation and reduce the risks of toxic substances, except liver, intestine and the achievement of the brain, causing drowsiness, confusion and coma (hepatic encephalopathy ).
  • Some patients have bleeding from ruptured esophageal varices in the lower part can be placed on a drug called propranolol, which reduces the pressure in the veins and reduces their chances of re-bleeding.
  • Finally, the liver can be considered marginal in patients with cirrhosis.

How Hepatitis Infection

Hepatitis, which is most often caused by viruses, but can also be caused by chemicals, drugs, alcohol, inherited diseases or autoimmune diseases. Inflammation can be sharp, bright, and then resolve in a few weeks to several months, or chronic, lasting for many years. Chronic hepatitis may persist for 20 years or more before causing significant symptoms related to progressive liver disease such as cirrhosis, liver cancer or death.

                                                                            figure via topnews
The liver is an important organ in the upper right abdomen. performs many functions in the body, including the processing of nutrients in the body, production of bile to help digest fats, synthesizing many important proteins that regulate blood clotting, and distribution of potentially toxic harmless in the body can use or excrete. Inflammation may (in severe cases) to interfere with these processes and allow potentially toxic substances to accumulate.

Summarizes The Common Types of Hepatitis
  1. Viral infection, a hepatitis virus leads to inflammation may be acute or chronic, depending on the virus. Examples of reasons: the United States are the most common cause of hepatitis A, B and C viruses.
  2. Chemical or drug, the liver processes of many substances for the body to use and / or subsequently removed. Some of these substances are toxic to the liver and can lead to hepatitis. Examples of causes: acute or chronic exposure to alcohol, paracetamol.
  3. Inherited mutations in certain genes, which are transmitted from one generation to another can lead to disease, which destroys the liver, causing hepatitis. Examples of reasons: Wilson disease, hemochromatosis, alpha-1 antitrypsin
  4. Non-alcoholic Fatty Liver Disease (NAFLD), Fat deposited in the liver by increasing amounts of lead to reduce the amount of liver tissue. Examples of reason associated with metabolic syndrome.
  5. Autoimmune diseases, the immune system produces antibodies against correctly liver tissue. Examples of reason associated with type I diabetes, Sjogren's syndrome

Signs and Symptoms
Symptoms of hepatitis are the same, whatever the cause, but they differ from person to person and may change over time. Many people have little, soft, and / or vague symptoms that can be confused with the flu. Some of the most common symptoms are:

  • Fatigue

  • Nausea

  • Stomachache

  • Joint pain

  • Itch

  • Jaundice

Some people may experience additional symptoms such as loss of appetite, dark urine color, color, light and stools. More serious complications can include fluid accumulation in the abdominal cavity (ascites), and confusion.
The test can show that the liver is tender and enlarged. Chronic hepatitis usually causes no symptoms or may be visible only as a loss of energy and fatigue. In some people, chronic hepatitis can gradually damage the liver and after many years, the causes of liver failure. Chronic form usually takes several years and rarely goes without treatment.
Laboratory Tests
There are several laboratory tests that can be applied in the case of known or suspected hepatitis. These tests can be used for various reasons, and may belong to one or more of these categories:

  • General chemistry tests used to detect inflammatory lesions in the liver and / or damage

  • Screening tests used for detection of hepatitis, such as research on the effect of hepatitis B or hepatitis C can be made because of an increased risk of disease (drug use, many sexual partners) or at the time of blood collection.

  • The tests used to diagnose the causes of

  • Further studies are used to monitor the progression of hepatitis and / or guided therapy

Acute hepatitis is often suspected, and testing because of symptoms such as fever, loss of appetite, nausea, often with black stools, and yellowing of the skin and whites of the eyes ( jaundice or jaundice).
Chronic hepatitis is usually detected as a result of abnormal results of routine tests. The patient is not having too few symptoms or wave of hepatitis can be discovered during routine tests, such as the comprehensive metabolic Group (CMP).
CMP is often a group of tests ordered as part of the annual review. It includes several tests of liver function panel. Research can be the first sign of liver inflammation or damage. Although these studies may help detect hepatitis, does not specify the cause. Additional tests may be needed to identify the cause and help direct treatment.
In addition to the CMP, other general criteria can be used to detect liver damage and advises on how they can be heavy. Some of them are listed below:

  • Alanine Aminotransferase (ALT) - an enzyme found mainly in the liver, the best test to detect hepatitis

  • Alanine Aminotransferase (AST) - an enzyme in the liver and some other places, especially the heart muscles and other

  • Alkaline Phosphatase (ALP) - an enzyme associated with the bile ducts, often when they are blocked, but can also be increased bone

  • Gamma-Glutamyl Transpeptidase (GGT) - enzymes in the liver, which is very sensitive to changes in liver function, helps to distinguish the causes of elevated ALP, GGT, if increases, then due to increased liver ALP , bone disease.

  • Bilirubin - a product made from waste decomposition cell old, he is a yellow compound that causes jaundice and dark urine, when present in increased quantities.

  • Albumin - measures the main protein in the liver and advocates, as well as the liver, which is the protein

  • Total proteins - albumin and other proteins in the blood, including antibodies that help fight against infections

  • Prothrombin time (PT). This test can be ordered in a person with hepatitis or suspected hepatitis. Proteins used in the formation of blood clots (coagulation factors) are mostly produced in the liver and prolonged PT may indicate the degree of liver injury.

  • Liver biopsy, in which the needle is inserted into the liver to remove a small amount of cells are examined under a microscope by a pathologist, is the most crucial to diagnose the disease. Because it is an invasive procedure, it is mainly used when other tests are inconclusive, or to determine the extent of liver damage has occurred.

Imaging tests such as ultrasound and X-ray specialist can be used to evaluate liver function, to detect hepatitis, help make a diagnosis and help identify the cause of the color of the injury.

via labtestsonline