Dengue fever is a disease that there are more mainstream in children and adolescents or adults with clinical signs include fever, muscle pain and / or joint pain, accompanied by leukopenia, with or without rash, and limfodenopati, bifasik fever, headache great, pain on eye movement, impaired taste on the tongue, mild thrombocytopenia, and spontaneous petekie. Dengue hemorrhagic fever or dengue hemorrhagic fever is a disease found in children and adults with primary symptoms of fever, muscle and joint pain, usually worse after the first two days. Spastic syndrome of dengue hemorrhagic fever is a disease accompanied by seizures.
Dengue virus is transmitted by Aedes aegypti and Aedes albopictus as a vector that will carry the virus into the human body through mosquito bites. The first infection can give symptoms as dengue fever. If that person gets repeated infections by different dengue virus type will cause a different reaction. Dengue Haemorrhagic Fever can occur when someone who has been infected with dengue the first time, had recurrent infections of other dengue virus. the virus to replicate in the regional lymph nodes and spread to other tissues, especially the reticuloendothelial system and skin as well as haematogenous bronkogen. The body will form virus-antibody complexes in blood circulation and therefore would lead to activation of the complement system resulting in the release of C3a and C5a anafiloksin thus increased permeability of blood vessel walls. Will occur also release ADP platelet aggregation, thrombocyte vasoaktif release that are increasing capillary permeability and the release of thrombocyte three factors that can stimulate intravascular coagulation. The occurrence of Hageman factor activation (factor XII) will cause widespread intravascular coagulation and increased permeability of blood vessel walls.